Nicotinamide has a variety of effects and is often used in whitening and freckle, anti-wrinkle and moisturizing cosmetics.

Nicotinamide can reduce skin pigmentation.

Nicotinamide can play a role in the process of melanin precipitation to prevent melanin from precipitating from melanocytes to keratinocytes.

Studies have shown that nicotinamide can effectively reduce melanin precipitation, promote spot color desalination and improve skin condition.